Cohort studies · Fringe modalities in real time

What actually moves the needle?

Every cohort study here is a single modality, tracked across 5–12 real kids in real time. We follow each child through the full arc — what shifts, what stalls, what's worth 12 weeks and what's noise. Published as the signal emerges.

What does healing look like?

Not a straight line. Which signals appear first, which follow, and which never come back?

What does stalling out look like?

When a modality runs out of room. Before the parent has sunk twelve more weeks into it.

How do we order these modalities?

Sequence matters. Which come before which? Where does the bottleneck actually live?

Featured · Study № 01

Active · Recruiting

The modality

The Amy Yasko protocol,
synthesized through AI.

Yasko's holistic methylation work is extensive, technical, and almost impossible for a parent to work through alone. Plan B reads each kid's full SNP panel, symptom history, and current treatments — and maps them to the Yasko framework in language the parent can actually use. This study follows ten kids for six months as the AI-synthesized protocol runs alongside their existing care.

kids tracked

6 mo

observation window

SNP-matched

personalization

Open

journal — posted weekly

Questions the study answers

What percentage moved the needle?

Measurable change in rage, OCD, sleep, cognitive load, or regression markers — within 90 days.

What worked?

Which specific protocol components, in which sequence, showed clean signal across multiple kids.

What didn’t?

What was tried, held, or escalated — and produced nothing, or made things worse. Those matter too.

More studies in progress

Recruiting

Active — tracking

Early signal

Queued

Recruiting5 kids

Phage therapy for strep-triggered PANS

Targeted bacterial phages for recurrent strep carriers

Active — tracking8 kids

Craniosacral + SSP paired

Nervous-system-first approach before any pharma titration

Early signal12 kids

Mold remediation + binder protocols

Does a clean home change the protocol, or obviate it?

Active — tracking6 kids

Peptides in pediatric PANS

BPC-157, KPV, TB-500 — sequencing, dosing, what responds

Active — tracking7 kids

DNRS / limbic retraining in dysregulated kids

Can nonverbal/severe kids do the work? Where does it land?

Active — tracking10 kids

Joan Randall protocol — biomagnetism for Lyme

Lyme-specific biomagnetic pairings, session-by-session shifts, sustained change

Recruiting6 kids

Homeopathy (constitutional, classical)

Where does individualized remedy-matching land for PANS/autism?

Queued5 kids

Low-dose naltrexone in pediatric PANS

Mixed anecdotal reports — what does a real cohort show?

Queuedintake open

HBOT for cognitive rebound

Does 40-session hyperbaric move the regression window?

§ How we order

Sequence is a modality.

Trying everything at once is how parents burn out and miss the signal. Plan B's read of your kid suggests an order — what to try first, what to hold, what to rule out before investing twelve weeks in something blocked behind an earlier bottleneck.

Remove the biggest inhibitor first

Mold, active infection, ongoing exposure. The body can’t heal while the bucket is still filling.

Stabilize the nervous system

Dysregulated kids need a regulated ground state before any protocol shows a clean signal.

One variable at a time, two weeks minimum

Unless the modality is designed to run in parallel. Stacking hides what worked and what didn’t.

Trust the stall, not just the gain

A modality that stops working after initial gains is telling you something about the next bottleneck.

Join us

Your kid's pattern is someone else's map.

These cohort studies get built from your Tuesday log, not a paper. Track with Plan B — consent-based, de-identified — and your family's signal helps the next family skip the dead ends.

Want your kid in a cohort study? Complete the full Plan B intake. Cohorts are matched on profile — we place kids where the modality actually fits their kid, so every study starts from aligned data.

Complete the intake →