Strep titers — ASO + anti-DNase B
The two antibody tests for strep exposure. Run both.
For the parent of a child with PANS or PANDAS
If your child was just diagnosed with PANS or PANDAS — or you suspect it — this is the complete list of tests they need. Every one explained in plain language. Every one you can order yourself if you have to.
We are not doctors. We are parents who have been where you are. We have watched our kids change overnight. We have sat across from pediatricians who told us to "wait and see." We have learned, slowly and at great cost, that most of the testing your child needs is testing your standard pediatrician has never heard of.
This page is the workup we wish someone had handed us on day one. Print it. Take it to the doctor. Demand each test. If they won't run it, we'll show you how to get it yourself.
How to actually get them
Here's the secret: doctors respond differently when a parent shows up informed, with specifics, and a clear plan. Name the tests, and most will order at least the standard, insurance-covered ones. The rest you order yourself — almost everything on this page can be ordered without your pediatrician — then bring the results back.
There are three routes, and most families use all three. Each test below lists exactly where to order it.
No doctor · ~most of this page
Order online, get a lab requisition signed by their physician network, walk into a LabCorp or Quest draw site, results come to you. This covers most of the bloodwork here — vitamin D, ferritin, CBC, immunoglobulins, ASO / anti-DNase B, thyroid, histamine + tryptase.
No doctor · collected at home
A kit arrives, you collect at home (saliva, stool, urine, or a nasal swab), mail it back. This is the route for the tests a draw site can't do.
*Run an AncestryDNA or 23andMe raw-data file through StrateGene (free) for methylation SNPs. Note: 23andMe went through bankruptcy and its database was sold — AncestryDNA or Nebula Genomics are privacy-safer ways to get the same raw file.
One visit · orders anything
A few specialty tests (full IGeneX tickborne panels, the immune workup that leads to IVIG) need a clinician's requisition. A PANS-literate telehealth provider can order all of them in a single visit — far easier than convincing a skeptical pediatrician. Many tickborne labs also allow direct ordering in most states.
Not sure which tests your kid needs, or the cheapest route for each? A Plan B Synthesis builds the exact list, prioritized, with where to order every one.
Then upload them
Upload your results and Minta tells you what actually matters — which findings are significant, what they mean for your child, and why. Then she brings every result together under one umbrella — labs, symptoms, and history — and hands you a clear direction with a why behind every step, not a pile of disconnected numbers no one connected.
You don't need all of these at once. Start with a few, upload them, and let Minta lead you out.
Why this exists
PANS and PANDAS look like sudden-onset OCD, intrusive thoughts, rage, regression, food refusal, tics, sleep loss — out of nowhere, often after an infection. It's not a "phase." It's an inflammatory immune response in the brain, almost always triggered by something measurable: an infection, a toxin, a mold exposure, or an underlying biochemical vulnerability. Standard pediatric workups miss almost all of it because the tests aren't part of standard care.
There are six categories of testing every PANS/PANDAS kid should have. Each tells a different part of the story.
At a glance
7 tests · the most common cause
N°. 025 tests · how the immune system is responding
N°. 037 tests · the Walsh-aligned methylation, mineral & nutrient workup
N°. 044 tests · mold, heavy metals, biofilm infections
N°. 054 tests · the second brain, often the root
N°. 061 test · once, forever, IntellxxDNA
Almost every PANS/PANDAS case is triggered by an infection — usually one your child has already had, often months or years ago, that the body never fully cleared. Strep is the most common (the “S” in PANDAS), but it’s far from the only one. These tests find what triggered your child’s flare and what may still be active.
The two antibody tests for strep exposure. Run both.
The second most common PANS trigger.
Epstein-Barr Virus reactivation. The four-panel — not just one.
The other common viral PANS triggers.
Specialty labs only. Do not let your doctor talk you into a standard ELISA.
Drug-resistant staph in the nasal cavity. The hidden infection most pediatricians don't know to test for.
A diagnostic test we don't routinely recommend.
PANS is fundamentally an immune disorder — the immune system has gone after the brain. These tests tell you how your child's immune system is functioning, whether it's deficient, whether it's autoimmune, and whether IVIG might help.
The most important immune test most pediatricians never run.
The other immunoglobulins — round out the immune picture.
High-sensitivity inflammation markers + autoimmune screen.
Basic blood count — but read the differential carefully.
The Shoemaker biotoxin illness panel. Run if any mold or water-damaged building exposure.
This is the Walsh Research Institute workup — biochemical individuality. Every PANS kid has nutrient imbalances driving their symptoms. Copper toxicity drives intrusive thoughts. Pyrrole disorder drives stress intolerance. Undermethylation drives OCD. These tests find which biochemical pattern your child fits, and what to do about it.
The master methylation marker. Must be whole blood, not serum.
The pyrrole disorder test. Walsh's discovery.
The copper overload workup. Critical for OCD-presenting PANS.
The methylation cycle workup — three together tells the story.
The most undertreated deficiency in PANS.
Not just hemoglobin. Ferritin is the storage form.
Not just TSH. Most pediatricians stop at TSH and miss the picture.
Mold, heavy metals, and environmental toxins are massively underdiagnosed in PANS. A kid living in a water-damaged building, or with heavy-metal exposure, will not get better until the exposure is identified and addressed.
Mold toxin testing. The single most important environmental test for any kid with a mold-exposure history.
A long-term mineral pattern plus toxic-metal screen.
DMSA or DMPS challenge — pulls metals out so you can measure them.
Don't forget to test the house. Test the kid AND the building.
The gut and the brain are connected. Most PANS kids have measurable gut dysbiosis, leaky gut, candida, or stealth pathogens that drive inflammation and feed the brain symptoms.
The most comprehensive functional stool test.
A urine test that maps metabolism. Surprisingly powerful.
Rule out celiac BEFORE going gluten-free.
Two different tests for two different things.
Run once. Use for life. A DNA panel tells you which biochemical pathways are predisposed to weakness — methylation, detox, neurotransmitter, inflammation — so every supplement and treatment decision can be tailored.
The cheapest way to read your child's methylation SNPs. Almost everyone should start here.
A purpose-built methylation/detox panel that comes with a ready-made protocol.
The most comprehensive option — when a practitioner is guiding treatment.
Which one — and why
All three read the same DNA. The difference is curation, cost, and who orders it — not the underlying genes.
Bottom line: you almost never need more than one. Start with 23andMe → StrateGene; upgrade only if a practitioner is guiding you or you want a done-for-you protocol.
When your doctor pushes back
Most pediatricians have never heard of half this list. They will tell you it’s unnecessary. They will tell you to wait and see. They are wrong, and you are not.
Use this script — or print this page
"My child has been diagnosed with PANS / PANDAS. I’d like to order a comprehensive workup that includes infection triggers, immune function, biochemistry, environmental toxins, gut function, and a one-time genetic panel. I have a list of every test and the reasoning for each one. I’d like you to order what you’re comfortable ordering. Anything you won’t order, I’ll order through a direct-to-consumer lab — but I’d like the results to come back to your office so we can review them together."
Doctors respond differently when a parent shows up informed, with specifics, and with a clear plan. Most will order at least the standard insurance-covered tests if you can name them. The rest you order yourself, then bring back the results.
If your doctor won’t order them
Most of the tests on this page can be ordered without a doctor’s prescription. The standard chemistry, serology, and antibody tests (everything Quest and LabCorp run) are available direct-to-consumer in most states. Functional-medicine tests (Mosaic, Diagnostic Solutions, etc.) require a practitioner signature — but functional-medicine telehealth services like Rupa Health make this fast and cheap.
Quest panel ordering, no doctor needed, deeply discounted prices. The best general-purpose DTC lab for the standard tests on this page.
Quest's own direct-to-consumer portal. Slightly more expensive than Ulta but goes through Quest's site.
LabCorp partner. Good for LabCorp-specific draws when your local hospital uses LabCorp instead of Quest.
The gold-standard tick-borne disease lab. Direct consumer ordering allowed in many states.
Pyrrole disorder testing (the HPL test). Walsh-recommended lab. Direct order, ships kit to you.
MARCoNS / MRSA deep nasal swab. Ships a swab kit; you do the swab at home and return it.
Home mold testing — ERMI and HERTSMI-2. You collect dust with a Swiffer-like cloth and mail it in.
A clearinghouse for ALL the functional-medicine tests (Mosaic, Diagnostic Solutions, Vibrant, Cyrex, RealTime, etc.). A practitioner from their network can order anything for a flat fee.
Membership-based functional-medicine telehealth. Monthly fee includes a comprehensive panel and a practitioner to interpret.
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Plan B is a parent-driven knowledge base. We are not doctors. None of this is medical advice. Always work with a practitioner. But you deserve to know what tests exist.
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