What is EBOO therapy?

EBOO stands for extracorporeal blood oxygenation and ozonation, sometimes called ozone dialysis. Blood is continuously drawn from one vein, passed through a dialysis-style filter where it is oxygenated and ozonated, then returned through another vein. It is the most intensive form of ozone therapy, used at some integrative clinics for refractory chronic Lyme, co-infections, and mold or biotoxin illness. It is experimental and not FDA-approved for these uses.

How is EBOO different from 10-pass ozone or major autohemotherapy?

Major autohemotherapy (MAH) draws a single bag of blood, ozonates it, and reinfuses it. 10-pass cycles a larger volume out and back several times under pressure. EBOO goes further still: blood flows continuously through a filter membrane while being oxygenated and ozonated, treating a much larger total volume in one session. It is the most aggressive, most invasive end of the ozone spectrum, and rests on the thinnest evidence.

No. There is no controlled human trial showing EBOO cures Lyme, co-infections, or mold illness. The proposed rationale — oxidative microbial kill, oxygenation, immune modulation, and filtering inflammatory debris — is largely clinic-based and anecdotal, not proven. Anyone promising a cure is overstating what is known. It belongs on the deeper, refractory menu as an eyes-open option, not a guaranteed result.

Is EBOO safe for children?

EBOO is an invasive blood procedure that requires venous access and continuous extracorporeal circulation, with real procedural and oxidative-stress risks. It has been studied and used almost entirely in adults; pediatric use is rare and warrants extra caution. It is not a first-line move for a child, and should only ever be considered — if at all — for a genuinely refractory picture, with an experienced clinician, full screening, and eyes wide open about the thin evidence.

How much does EBOO cost?

EBOO is cash-pay and not covered by insurance for these uses. Sessions are commonly cited in the several-hundred to roughly one-thousand-dollar-plus range each, and providers typically recommend a series, so the cumulative cost adds up quickly. Reviews and pricing vary widely by clinic, and quality and honesty vary just as much.

Field Guide · The Deeper Menu

EBOO.
Ozone’s most intensive form, honestly told.

Sometimes called “ozone dialysis” or “ten-pass on steroids,” EBOO — extracorporeal blood oxygenation and ozonation — is the most aggressive form of ozone therapy. Blood is drawn from one vein, passed through a dialysis-style filter while being oxygenated and ozonated, then returned through another. It’s reached for in refractory chronic Lyme and co-infections, mold and biotoxin illness, and high inflammatory load. Here is the honest version: what it actually is, how it differs from the gentler ozone routes, the proposed rationale, what the human evidence really shows (very little), the real risks of an invasive blood procedure, and why this sits at the deep end of the menu — never a first move.

I walked this part of the labyrinth myself — knocked on the doors, read the research, and came back with the map. You don’t have to find the way out alone.

Read this first

EBOO is experimental and not FDA-approved for chronic Lyme, mold, or any infection or inflammatory use. It is an invasive blood procedure — continuous extracorporeal circulation through a filter — with real procedural and oxidative-stress risks. The human evidence for these uses is largely clinic-based and anecdotal, with little controlled data and essentially none in children.

It belongs on the deeper, refractory menu — something to understand and weigh carefully after gentler, better-studied options, not a first-line move. For most families exploring ozone at all, the broader, gentler routes (rectal insufflation, major autohemotherapy) come long before this. See the full ozone therapy entry for that bigger picture.

What it is

EBOO — extracorporeal blood oxygenation and ozonation — treats a large, continuous flow of blood outside the body. A line is placed in a vein; blood is pumped out through a dialysis-style filter membrane where it’s simultaneously oxygenated and ozonated; then it’s returned to the body through a second vein. Because the blood flows through a filter continuously rather than being treated one bag at a time, a single EBOO session passes a far larger total volume across the ozone than the other ozone methods — which is exactly why it’s described as the most intensive form, and why the dialysis comparison is apt.

The “filter” piece is part of the pitch: as blood crosses the membrane, providers describe it as also clearing some circulating debris — the visual of a darkened filter cartridge is a staple of EBOO marketing. That visual is striking, but it is not the same thing as proof of clinical benefit, and it’s worth holding that distinction firmly.

The mental model: if major autohemotherapy is a single glass of blood ozonated and poured back, and 10-pass is that glass cycled out and back several times under pressure, EBOO is the whole river run continuously through a filter while being oxygenated and ozonated. It sits at the far, most-intensive end of the ozone spectrum — the loudest-marketed and the least-proven. The intensity is the selling point. The intensity is also the risk.

How it differs from the other ozone routes

EBOO only makes sense next to its gentler cousins. The single thing to track: how much blood is treated, how invasively, and how much human evidence stands behind it. Safety and proof both track inversely with intensity — the gentler routes are better studied and lower risk; EBOO is the most aggressive and the thinnest on data.

Form	What happens	Intensity / invasiveness	Plan B read
Rectal insufflation	Ozone gas into the rectum — no needle, no blood draw, no gas in the bloodstream	Lowest — needle-free	The gentlest systemic route; where most curious families would start, if any
Major autohemotherapy (MAH)	~100–200 mL of blood ozonated outside the body and reinfused, one pass	Moderate — gas filtered out before reinfusion	The standard, most-studied systemic route
10-pass	A larger blood volume cycled out, ozonated under pressure, and returned — multiple times per session	High — pressurized, repeated cycling	Aggressive; thin data; not a first move for a child
EBOO (“ozone dialysis”)	Continuous flow of blood through a dialysis-style filter while oxygenated and ozonated — the largest total volume treated	Highest — the most intensive, most invasive form	Deepest end of the menu. Experimental, invasive, thinnest evidence. Not a first-line move; pediatric use rare & extra-cautious.

For the full picture on every ozone route, the gas-embolism rule, dosing, and the antioxidant reverse, see the ozone therapy entry →

The proposed rationale

Read this as “the case its proponents make,” not “what’s proven.” The mechanisms behind ozone are real in the lab; whether running them at EBOO intensity translates into a clinical win for a chronic-infection or mold picture is the unproven leap. The four threads of the argument:

Oxygenation. Forcing oxygen into a large, continuous volume of blood is claimed to improve tissue oxygen delivery in a body carrying a heavy infection or inflammatory load.
Oxidative microbial kill. Ozone is directly antimicrobial in experimental settings — it oxidizes the cell walls of bacteria and fungi and can disrupt the biofilms that shield them. The EBOO pitch is that treating a large blood volume amplifies this oxidative pressure on a stealthy, biofilm-protected infection.
Immune modulation. Controlled oxidative stress is described as retuning the immune system — shifting cytokines and nudging inflammation toward balance — the “retune, don’t just kill” angle.
Filtering inflammatory debris. Because EBOO runs blood through a membrane, providers describe it as clearing circulating inflammatory byproducts and debris as it goes — the darkened-filter visual. Plausible-sounding, but not validated as a clinical benefit.

The honest framing: the underlying biology of ozone isn’t made up — that’s why the chronic-infection world reaches for it. But the specific claim that EBOO-intensity treatment clears refractory Lyme or mold rests on clinical experience and anecdote, not controlled human evidence. The mechanism is the appeal. The missing proof is the catch.

The evidence — honest level: experimental, largely anecdotal, no pediatric data

Here’s the straight version. Ozone’s lab mechanisms are genuine, but the EBOO human evidence is the thinnest on this whole map. Open to it, not sold on it.

The human evidence is largely clinic-based and anecdotal

No controlled trials for chronic Lyme, co-infections, or mold. The use of EBOO for these conditions rests on clinical experience, practitioner testimonials, and patient anecdote — hypothesis-generating at best, not proof.
The broader ozone evidence is already fragile — even for the gentler, better-studied routes, the human treatment trials are small, mixed, and low-certainty, and major reviews call routine clinical use unjustified pending properly powered, blinded studies. EBOO, the most aggressive form, has less support than that, not more.
Almost no pediatric data. EBOO has been used and studied essentially in adults. Pediatric use is rare, and there is no body of evidence establishing its safety or benefit in children.

The regulatory reality

EBOO is not FDA-approved for chronic Lyme, mold, or any infection or inflammatory use. Medical ozone broadly is not recognized by the FDA as having an established medical application for these indications — so EBOO is unapproved, off-label, cash-pay territory. That doesn’t make every clinical claim false, but it means you’re weighing an experimental procedure outside the bounds of approved medicine, and you should weigh it accordingly.

The honest label: experimental, low-evidence, invasive. The lab science behind ozone is real, but no rigorous trial shows EBOO clears chronic infection or mold, nothing has been studied in PANS, and there is essentially no pediatric data. This is a “deeper-menu option to understand with eyes wide open,” not a “this works.”

The risks & who’s not a candidate

EBOO carries the oxidative-therapy risks of all ozone plus the risks of an invasive, continuous extracorporeal blood procedure. That combination is why it sits where it does.

It’s an invasive blood procedure. EBOO needs venous access and continuous extracorporeal circulation through a filter. That introduces the procedural risks of any such circuit — vascular access complications, bleeding, infection, fluid/circulatory stress, and reactions in the line — on top of the ozone itself.
Oxidative stress. You’re deliberately dosing a large blood volume with an oxidant; a body short on antioxidant capacity can feel worse before better, and the intensity here is the highest of any ozone route.
Hemolysis in G6PD deficiency. Oxidative red-cell damage is a known risk of oxidative therapy; G6PD should be screened before any of this.
The catastrophic ozone risk — gas embolism — must be engineered out by proper bubble-filtration and an experienced operator. This is precisely why an invasive route like EBOO demands a skilled, careful provider, not a casual one.
Cost. Cash-pay, not covered by insurance, typically a series — the cumulative cost is real.
Pediatric caution. Studied and used almost entirely in adults; pediatric use is rare and warrants extra caution. This is not a first-line move for a child, and arguably not a move for a child at all outside a genuinely refractory picture with an experienced clinician.

Hard cautions

Never a first-line move. EBOO belongs only on the deeper, refractory menu — after gentler, better-studied options.
G6PD unscreened — don’t start any oxidative therapy without it.
For a child — pediatric use is rare and the data essentially absent; extra caution, experienced clinician, full screening, and a clear-eyed acceptance of the thin evidence are the floor, not the ceiling.
Anyone promising it cures Lyme or mold, or who shrugs off the invasiveness and the embolism-prevention engineering, is the red flag — walk away.

When (if ever) to consider it

Honestly labeled: this is an experimental, low-evidence option at the deep end of the “what hasn’t been tried” menu, drawn from the oxidative-medicine / chronic-Lyme world. The places it’s reached for:

Refractory chronic Lyme & co-infections — a stealthy, biofilm-protected picture that hasn’t responded to better-studied approaches. See the Lyme entry for the fuller kill-and-keep-away menu that comes first.
Mold / biotoxin illness with high inflammatory load — where the “filter and retune” pitch is made. The mold protocol covers the foundational, lower-risk work (exposure removal, binders, drainage) that belongs long before something like this.
As an adjunct, never a replacement — if a family pursues it at all, it’s alongside — not instead of — properly indicated care, with antioxidant support and full screening, and only for a genuinely refractory case.

The Plan B read: EBOO earns a line on the deeper menu because the underlying mechanism is real and the refractory-infection world uses it — but it sits in the experimental, invasive, low-evidence tier, with essentially no pediatric data. We’d steer firmly toward the gentler, better-studied work first, and treat EBOO as a last-resort question for a refractory case — brought to your team as a question, never a plan, and never a first move for a child.

How to vet a practitioner

Credentials, polish, and how impressive the equipment looks tell you little about whether a practitioner will help your child — or harm them. What does: their behavior and their incentives. Watch those.

EBOO clinics range from careful and honest to aggressive and salesy — and a dramatic darkened-filter photo is marketing, not evidence. Don’t judge by the machine; judge the conduct and the incentives.

Red flags

Promises EBOO will cure Lyme, mold, or PANS — or shows you a dirty filter as “proof.”
Skips the G6PD screen or won’t talk plainly about the invasiveness, the oxidative-stress risk, and the embolism-prevention engineering before you start.
Pushes EBOO as a first move, or recommends it for a child as if the pediatric evidence existed.
Tells you to stop your other care, or dismisses your other doctors.
Sells you the sessions AND the testing AND a supplement stack (the conflict of interest), and won’t admit the human evidence is thin and the procedure unapproved.

Green flags

Honest that this is experimental, invasive, and not FDA-approved, and that the human evidence is largely anecdotal.
Screens G6PD and builds in antioxidant support; explains the procedure and its risks plainly, and uses proper bubble-filtration with an experienced operator.
Reserves it for genuinely refractory cases after the gentler work — and is cautious-to-reluctant about a child.
Names the risks before you ask, welcomes your other doctors and second opinions, and reassesses on how the child is actually doing.

Bottom line

EBOO — extracorporeal blood oxygenation and ozonation, “ozone dialysis” — is the most intensive form of ozone therapy: blood run continuously through a dialysis-style filter while oxygenated and ozonated. The proposed rationale (oxygenation, oxidative microbial kill, immune modulation, filtering inflammatory debris) draws on real lab mechanisms, but the human evidence for refractory Lyme, co-infections, and mold is experimental, largely clinic-based and anecdotal, with little controlled data and essentially none in children. It is an invasive blood procedure with real procedural and oxidative-stress risks, it’s expensive and cash-pay, and it is not FDA-approved for any of this. So it’s a real but deep-end, low-evidence option on the “what hasn’t been tried” menu, labeled honestly — never a first-line move. If it ever reaches your table: it belongs only after the gentler, better-studied work, only for a genuinely refractory picture, only with G6PD screening and antioxidant support and an experienced operator — and for a child, with extra caution, because pediatric use is rare and unproven. This is parent education, not medical advice — bring it to your team as questions, not instructions.

How Plan B stays honest

Plan B does not partner with drug companies or doctors, and we never endorse anyone whose healing isn’t verified by families. We show you the options and how to vet them yourself — and we’re building parent verification: look up a clinic or practitioner and see real family reviews before you trust them. Universal bad reviews? Skip.

This is a lot to weigh — and you don’t have to weigh it alone. Minta has all of this synthesized. She’ll look at your child and tell you honestly whether something like EBOO even belongs anywhere near your table — and what the gentler, better-studied moves are first.

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Ozone therapy (the full picture) · Chronic Lyme · Mold protocol

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EBOO.Ozone’s most intensive form, honestly told.